Paolo

Neuroimmunological diagnostics has accelerated incredibly in recent years, thanks to identifying many antibodies directed against neuronal and glial proteins, which represent fundamental markers for diagnosing neurological autoimmune diseases. In these diseases, which may include autoimmune encephalitis, neuromyelitis optica spectrum disorders, syndromes associated with anti-MOG antibodies, and myasthenia gravis, among others, antibodies may also have pathogenetic relevance, justifying the use of drugs immunosuppressants that block its production or function capable of leading to significant clinical improvements. The relevance of antibodies in identifying diseases that can be treated with specific therapeutic procedures has placed enormous pressure on neuroimmunology laboratories, which are required [...]

To identify the main critical issues of the Italian laboratories dedicated to neuroimmunological diagnostics, the Italian Association of Neuroimmunology (AINI) organizes an external quality control (External Quality Assessment Scheme, EQAS) from various sources. The principle of EQAS is to have a coordinating laboratory circulate several samples to be tested on different laboratory tests that cover the main areas of neuroimmunological diagnostics. Through the concordance or discordance of the results, it is then possible to identify: The performance level of each individual laboratory The level of standardization of specific diagnostic areas Any reasons that may explain the poor standardization, such as [...]